Figure 3.

Clinical observations in marmosets challenged with SARS-CoV-2 by the aerosol route. Remote telemetry was used to monitor core body temperature (Tc) in marmosets. Normal diurnal temperature ranges between 38–39 °C during the day and 36–37 °C at night. The mean hourly temperature (black line), the expected temperature (using baseline data for each individual animal; dark red line), and the expected temperature ±1 SD (bright red shaded area), ±2 SD (red shaded area), and ±3 SD (pink shaded area) are shown for (A) M1, (B) M3, (C) M4, (D) M5, and (E) M6 from days 0 to 8 post-challenge. ★ Indicates Tc > 3 SD than the expected Tc (note that there is no Tc data for M2 due to failure of implant). (F) Animals were weighed prior to the challenge to determine baseline weights and daily throughout the study. Data is presented as the percentage body weight change for each animal, or the mean of all animals. A mixed-effects model was used to determine statistical difference in weight change with time where ns—not significant and ** p = 0.007.