Appendix 1—table 1. Model discrimination and improvement estimated with area under the curve (AUC) upon adding the multi-ancestry polygenic risk score (PRS) to a base model in the Million Veteran Program (MVP) study populations.
| Age and PCs | Age, PCs, and PRS | AUC Change | ||||
|---|---|---|---|---|---|---|
| Population | Sample | AUC | 95% CI | AUC | 95% CI | |
| European ancestry | All cases and controls | 0.582 | (0.578–0.587) | 0.694 | (0.690–0.699) | +0.112 |
| Aggressive cases and controls | 0.533 | (0.521–0.545) | 0.666 | (0.655–0.677) | +0.133 | |
| Nonaggressive cases and controls | 0.603 | (0.598–0.608) | 0.703 | (0.698–0.708) | +0.100 | |
| African ancestry | All cases and controls | 0.512 | (0.505–0.520) | 0.656 | (0.649–0.663) | +0.144 |
| Aggressive cases and controls | 0.547 | (0.531–0.564) | 0.681 | (0.665–0.697) | +0.134 | |
| Nonaggressive cases and controls | 0.522 | (0.514–0.529) | 0.657 | (0.649–0.665) | +0.135 | |
| Hispanic | All cases and controls | 0.530 | (0.513–0.547) | 0.683 | (0.667–0.699) | +0.153 |
| Aggressive cases and controls | 0.568 | (0.531–0.607) | 0.674 | (0.636–0.712) | +0.106 | |
| Nonaggressive cases and controls | 0.514 | (0.495–0.534) | 0.685 | (0.667–0.702) | +0.171 | |
Abbreviation: PCs, principal components of ancestry.