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. 2022 Jul 13;11:e73671. doi: 10.7554/eLife.73671

Table 2. Modelling results of educational attainment in the UK Biobank.

Full sample
Unweighted PRS Weighted PRS
Estimate Std Error p-value Estimate Std Error p-value
Offspring effect 0.026 0.005 3.18 × 10 -7 2.474 0.485 3.40 × 10 -7
Prenatal maternal effect 0.027 0.011 0.013 1.722 0.703 0.014
Postnatal maternal effect –0.006 0.008 0.484 –0.288 0.514 0.575
Postnatal paternal effect 0.018 0.007 0.006 1.233 0.678 0.069
Excluding adopted individuals with breastfeeding information
Unweighted PRS Weighted PRS
Estimate Std Error p-value Estimate Std Error p-value
Offspring effect 0.025 0.005 5.52 × 10–7 2.441 0.372 5.15 × 10–11
Prenatal maternal effect 0.017 0.012 0.140 0.909 0.705 0.197
Postnatal maternal effect 0.004 0.009 0.682 0.549 0.595 0.357
Postnatal paternal effect 0.019 0.007 0.005 1.273 0.552 0.021

PRS: polygenic risk score constructed using 1,267 SNPs from Lee et al., 2018; Std Error: standard error.