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(A) Isothermal rolling circle amplification (RCA)-based assembly and acid-stimulated disassembly of nanosponge-based delivery systems containing doxorubicin (DOX), DNAzyme, and ZnO nanomaterials. (B) The intracellular dissolution of ZnO into Zn2+ ions can induce the formation of ROS and activate the cleavage of DNAzyme along with the stimulated release of the anticancer drug after specific uptake by cells. Adapted from [71] with permission. Copyright 2019 American Chemical Society.
