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. 2022 Jul 15;23(14):7824. doi: 10.3390/ijms23147824

Figure 2.

Figure 2

Expression of genes related to stemness and drug resistance in MIA-G cells. (A,B) Sensitivity to 5-FU and CDDP in MIA-P and MIA-G cells. (C) Protein levels of factors associated with EMT, stemness, multidrug resistance, and AKT signaling. In MIA-P cells, protein could not be extracted by GEM treatment due to cell degradation and death. (D) mRNA expression of genes associated with drug resistance. Error bars represent standard deviations from three independent evaluations. * p < 0.05. MIA-P—MIA-PaCa-2; MIA-G—MIA-PaCa-GEM; 5-FU—5-fluorouracil; CDDP—cisplatin; EMT—epithelial–mesenchymal transition; AKT—AKT serine/threonine kinase; NS—nucleostemin; MDR—multidrug resistance protein 1; RELA—nuclear factor kappa-light-chain-enhancer of activated B cells 3; ACTB—β-actin; hENT—human equilibrative nucleoside transporter 1; dCK—deoxycytidine kinase; RRM—ribonucleotide reductase; MRP1—multidrug resistance-associated protein 1.