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Proposed HIV-1 myristoylation at the molecular level. (A) Full length Gag polyprotein with a myristoylated MA at the N-terminal domain. (B) Sequestered (S) and Exposed (E) transition states in different MA conformations [37]. (C) The sequestered myristic acid switches to exposed upon PIP2 binding at the plasma membrane. The PIP2 fatty acid is then sequestered into the vacant hydrophobic pocket (adapted from [38]).
