Table 3.
Different forms of bee pollen for immunity-related disorders.
| Inventor | Country | Ingredients/Patent Form | Patent Title/Patent Number/Patent Office | Features and Benefits | References |
|---|---|---|---|---|---|
| Di, D.; Pei, D. | China | 0.01–0.2 g/mL wall-broken bee pollen, 0.01–0.2 g/mL Lycium barbarum, 0.01–0.1 g/mL honey, 80 0.0005–0.003 g/mL tween, 0.0004–0.005 g/mL xanthan gum, glyceryl monostearate 0.0005–0.005, carrageenan 0.0004–0.005, sodium alginate 0.0004–0.005, citric acid 0.002–0.008 g/mL, and water/oral liquid | Oral liquid containing bee pollen and Lycium barbarum and manufacture method thereof/CN 102,742 894 A/CN | Improves immunity and fatigue resistance, and nourish the skin. |
[76] |
| Di, D.; Pei, D.; Liu, J. | China | Parts by wt.%: 40–50 wall-broken Fructus lycii bee pollen, 15–20 Radix codonopsis extract, 10–15 lyophilized powder of spirulina, 5–10 filler, 3–5 lubricating agent, and 1–2 essence/ND | Anti-tumor health-care food containing fructus lycii bee pollen and preparation method thereof/CN 109315739 A/CN | Improve immunity throughout human body. | [77] |
| Zhang, J. | China | By wt.%: 10–95 bee pollen and 5–90 Gynostemma pentaphyllum/tablet | Method for manufacturing health care food containing gynostemma pentaphyllum and bee pollen/CN 102302107 A/CN | Increase human immunity. Decrease blood pressure, blood lipid, and sugar. Prevent tumors by inhibiting and killing cancer cells. |
[78] |
| Shao, S. | China | Parts by wt.: 150–180 bee pollen, 10–30 plant extract, 10–20 pupa worm intestinal extract, 10–20 modified dietary fiber, 7–15 oligosaccharide, 2–6 Lactobacillus plantarum powder, 2–6 hydroxyl isomaltulose, and 2–6 mango powder/tablets, electuary, capsules | One kind of bee pollen for improving immunity and its preparation method/CN 105,831,759 A/CN | Improves immunity. | [79] |
| Liang, J. | China | bee Pollen, taizishen, longan tree parasitic, mushroom, and amino acids/ND | A Chinese medicine composition to improve immunity and preparation method thereof/CN 104257722 A/CN | Improving immune function. Quick impact and simple in preparation and execution. |
[80] |
| Miao, J. | China | Parts by wt.: 20–30 bee pollen, 30–50 honey, 20–30 honey lyophilized powder, 15–25 soybean lecithin powder, 10–20 spinach, 10–20 oligofructose, and 5–10 low-fat milk/capsule | Capable of improving immunity of honey pollen capsule/CN 106,666,595 A/CN | Improves immunity, high nutritional value, low cost, and simple to prepare | [81] |
| Miao, J. | China | Parts by weight: 20–30 bee pollen, 30–45 honey, 20–30 honey, 20–25 Radix Astragali, 15–20 mushroom, 10–20 matrimony vine, 10–20 parts of FOS, 5–10 American ginseng, 25 ferrous lactate/capsule | A kind of honey pollen capsule for fatigue/CN 106,962,862 A/CN | Improves immunity, fatigue resistance. | [82] |
| Liu, J.; Sui, Y. | China | Parts by wt.: 1–2 bee pollen, 10–20 kiwi flower, 5–10 blueberry, 50–100 honey, 2–5 honeysuckle, 2–4 Cortex eucommiae male flower, and 5–10 camellia/powder | Flower tea product and preparation method thereof/CN 112,868,847 A/CN | Enhance immunity, prevent cardiovascular diseases, antibacterial, anti-inflammatory, and hepatoprotective properties. Easy to prepare and low cost. | [83] |
| Ding, H. | China | Parts by wt.: 10–40 bee pollen, 20–60 honey, 20–60 royal jelly, 1–10 bee glue, 20–30 bee placenta, 2–9 ginseng, 3–12 pseudo-ginseng, 5–18 dogwood fruit, 3–12 Rhizoma alismatis, and 5–20 Chinese wolfberry/ND | Bee-product-containing health product/CN103,238,771 A/CN | Improves immunity, expel toxins, beautify the face, anti-aging, and beneficial for the brain, kidneys, tendons, and for bone strengthening. | [84] |
| Liu, J. | China | Parts by wt.: 0.01–0.015 bee pollen, 70–90 wheat flour, 5–15 wheat malt powder, 0.001–0.005 lotus root polysaccharide, 0.006–0.01 selenium-enriched yeast, 1.8–2.2 peanut sprout powder, 0.1–0.5 modifier, 0.005–0.008 corn peptide, and 0.015–0.02 white tea powder/ND | Corn peptide selenium-rich polypeptide nutrition flour/CN 104,000,080 A/CN | Improves immunocompetence. | [85] |
| Bai, W. | China | By wt.%: 35–50 bee pollen (purity > 98 wt.%), 35–50 propolis powder (purity > 90 wt.%), 2–4 VC, 10–15 and auxiliary additive/capsules | Health food with vitamin C/propolis compound capsules/CN 102,132,810 A/CN | Improves immunity; regulate blood pressure; fatigue and insomnia resistance. High nutrition, high active ingredient content, low dose, low cost, and no side effects. |
[86] |
| Liu, Y. | China | By wt. %: 68–72 bee pollen, 8–12 honey, 18–22 Ampelopsis grossedentata, and water for balance. | Method for manufacturing healthcare tea containing bee pollen, honey, and Ampelopsis grossedentata/CN 102,224,867 A/CN | Improves immunity, decrease blood pressure, help in body weight loss, and inhibit laryngopharyngitis. | [87] |
| Zhao, J. | China | By weight percent: 60–95 bee pollen, 5–30 Ginkgo biloba extract, and 0–10 starch/tablets or capsules | Method for preparing healthcare food from Ginkgo biloba extract and bee pollen/CN 101,669,640 A/CN | Improves immunity, prevent cardiovascular diseases, decrease lipid level, anti-aging, and beautifying skin. | [88] |
| Chen, Wi; Chen, X. | China | By wt.: 10–40 bee pollen, 20–60 honey, 20–60 royal jelly, and 1–10 propolis/ND | Formula of bee products for improving immunity/CN 102,125,196 A/CN | Improves immunity. | [89] |
| Yin, W.; Yin, Z. | China | Weight of parts: 10–60 bee pollen, 2–20 propolis, 2–20 royal jelly, 2–15 bee embryos, 2–15 been pupae, and 2–10 Panax quinquefolium/ND | Method for manufacturing honey product preparation for improving immunity/CN 102,150,770 A/CN | Improves immunity, decrease blood lipid, fatigue resistance, and anti-aging. | [90] |
| Zheng, Z. | China | Parts of raw materials by weight: 1–5 bee pollen, 10–15 Salvia miltiorrhiza, 12–18 bioflavonoid, 5–10 soybean functional polysaccharide, and 2–6 Fructus lycii/ND | Natural food additive/CN 111,134,318 A/CN | Improves immunity and inhibit cancer. Decrease blood sugar and blood lipids in human body. Used as food additive due its antioxidant and bacteriostasis effects. |
[91] |
| Shao, S. | China | Parts by weight: 50–70 bee pollen of maize extract, 35–50 corn oligopeptide powder, 10–20 modified dietary fiber, 10–20 fruit vegetable powder, 5–20 pectin decomposer, 3–12 chrysanthemum powder, 2–10 sophora flower powder, 2–10 isomalt/ND | One kind of bee pollen for preventing and treating liver disease and enhancing the immune system and its production method/CN 104686883 A/CN | Improves immunity, and protect liver. | [75] |
| Ren, X. | China | Parts by weight: 8–12 bee pollen, 4–6 medlar, 4–6 yam, 5–7 chrysanthemum, 4–6 Gordon euryale seed, 1–5 pearl barley, 2–4 red bean, 2–6 prepared Rehmannia root, 4–8 dogwood, 4–8 tuckahoe, 1–3 tree peony bark, and 0.5–1.5 oriental waterplantain rhizome/granule powder | Nutrient instant powder/CN 111671082 A/CN | Improve immunity, enhancing sleep, and anti-aging. Used as supplement. |
[92] |
| Zhong, H. | China | Wt. in parts: 3–5 lotus bee pollen, 3–5 linden bee honey, 1.0–1.5 protease, 1.0–1.5 wine yeast, and 88–92 purified water/ND | Method for manufacturing healthcare wine from honey and pollen/CN 102911834 A/CN | Strengthen immunity, support to the liver and kidneys, lower blood pressure, and moisturize the skin. | [93] |
| Liang, Z. | China | By weight percent: 0.5–3 bee pollen, 5–18 Pseudo-ginseng, 5–12 Ginkgo biloba extract, 12–22 glucose syrup, 18–55 granulated sugar, 4–15 powdered milk, and 10–18 petal/powder | Fragrant health candy containing Panax notoginseng for resisting fatigue, anoxia, and aging, as well as reducing blood fat and sugar/CN 102058005 A/CN | Improves immunity, combats exhaustion and oxygen depletion, anti-aging, anticancer; decrease blood fat and sugar. It has nutritive value, good fragrance, and stable quality. |
[94] |
| Liu, J.; Yin, Y. | China | Wt. parts: 5–25 bee pollen, 25–55 royal jelly, 15–35 honey, and 15–35 wolfberry powder/ND | Composition for improving sexual function of men/CN 105433328 A/CN | Enhance immunity and improve male sexual function. | [95] |
| Wang, L.; Sui, L. | China | By wt. parts: 3–9 bee pollen, 1–5 Chrysanthemum morifolium, 1–5 Shizhu Panax ginseng, 3–9 Acanthopanax sessiliflorum, 3–9 Poria cocos, 3–9 Sesamum indicum, 1–5 Semen Persicae, 1–5 Tremella fuciformis, 1–5 Auricularia auricula, 1–5 Hericium erinaceus, 2–8 Lentinus edodes, 1–5 grape seed, 0.02–0.06 lycopene, and 0.5–1.5 royal jelly/ND | Health food with antioxidation function and its manufacture method/CN 101518336 A/CN | Enhance immunity. | [96] |
| Li, W.; Liu, S. | China | Fresh milk and bee pollen as main materials, adding fractions of sucrose, nourishing sugar (cerealose or glucose), and maltodextrin/milk powder | A health promotion milk powder containing bee pollen\CN 1108477 A\CN | Increased immunity and improved human physiology. | [97] |
| Inventor not announced | China | By wt. parts: 10–90 Rabdosia serra and 10–90 bee pollen/tablets, granules, and capsules | Healthcare food made from Linearstripe isodon herb and bee pollen and processing method thereof/CN 102302106 A/CN | Detoxification, delaying aging, protecting the liver, and increasing human immunity. | [98] |
| Inventor not announced | China | By wt. parts: 10–40 Berchemia lineata and 60–90 bee pollen/tablets, capsules, and granules | Method for manufacturing healthcare food containing Berchemia lineata and bee pollen/CN 102302105 A/CN | Increase human immunity. Good for patients with tuberculosis, diabetes, gastric ulcers, testitis, spermatorrhea, rheumatoid arthritis, lumbar genu ache, traumatic injury, and urticaria. | [99] |
| Inventor not announced | China | By wt. parts: 60–95 bee pollen and 5–40 lycopene/tablets, granules, and capsules | Method for manufacturing healthcare food containing lycopene and bee pollen/CN 102302104 A/CN | Increase immunity, treat heart and cerebrovascular diseases, and good for patients with tumors, hepatitis, anemia, and diabetes. | [100] |
| Li, G.; Li, H. F. | China | By wt.%: 65–85 bee pollen (purity >= 80%) and 15–35 active casein peptides (purity >= 80%)/ND | Process for manufacturing health food containing peptides and bee pollen/CN 101889667 A/CN | Delay aging, improves immunity, and resist fatigue. |
[101] |
| An, X. | China | 500–800 g of bee pollen and 1000–1500 g of mature honey/ND | For prevention and treatment of malignant tumor for traditional chinese medicine compound preparation and preparation method thereof/CN 106344621 A/CN |
Improves gastrointestinal functions, good supplement for humans, beneficial for sleep. Strengthening chemoradiotherapy effects, improving immune function for patients with malignant tumors. | [102] |
| Long, L.; Wei, Z. | China | 0.1–10% bee pollen, 0.1–20% bamboo leaf extract, and 70–99.8% carrier/feed additive | Feed additive containing bee pollen and bamboo leaf extract for improving immunologic function of livestock and poultry/CN 109170172 A/CN | Significantly improves immunity of livestock and poultry. Promotes absorption and utilization of fat-soluble vitamins and other microelements. Novel feed additive, which is safe, efficient, and environmentally friendly. |
[103] |
| Zhang, G. | China | Bee pollen, Vaccinium, and Rosa davurica/ND | Production of healthcare food comprising Vaccinium, Rosa davurica, and bee pollen/CN 101449824 A/CN | Enhance heart function, improve eyesight, kill bacteria, improve immunity, reduce blood fat, and combat tumors. | [104] |
| Zhang, Q. | China | Bee pollen, rice flour, medlar, Zizania aquatica, apple juice, broccoli, sweet potato powder, white sugar, coix seed flour, walnut kernel, dried orange peel, honey, and olive oil/rice cake | Nutritional rice cake/CN 109170526 A/CN | Eliminating dampness and cold, enhancing immunity. | [105] |
| Bai, Z. | China | Tangerine bee pollen, tangerine honey, tangerine royal jelly, fritillaria, white peony root, andRadix Angelicae Sinensis/ND | Traditional Chinese medicine with tangerine honey/CN 108450866 A/CN | Protecting liver and kidneys, remove sputum from lungs, and strengthen immunity. | [106] |
| Gou, C. | China | Bee pollen, black wolfberry, maca, sheep placenta extract, royal jelly, Rhizoma polygonati, gelatin, semen coicis, walnuts, collagen, γ- linolenic, vitamin C, vitamin E/tablet | Lycium ruthenicum tablet as health product\CN 104126744 A/CN | Increase immunity, antioxidant, anti-aging, delay menopause, protect the liver, and has anti-tumor effect. | [107] |
| Lin, J | China | Raw material drug by weight: 1–2 rose bee pollen, 1–2 Fructuctus schisandrae bee pollen, 1–2 honeycomb extract, 1–2 END, 1–2 Eclipta alba, 1–2 Radix paeoniae alba, and 1–2 Prunella vulgaris | A bee pollen health product and method for preparation/CN 104083464 A/CN | Significantly controls endocrine secretion, improves immunity, relieves menopausal symptoms, enhances sleep, reduces migraines, reduces blood pressure, and decreases weight. | [108] |
ND: Not detected.