Table 2.
Risk factors for local recurrence, nodal metastasis, and disease-specific death in meta-analyses. Statistically significant risk ratios are marked in bold.
| Risk Factor | Thompson, 2016 [14] | Dessinioti, 2022 [15] | ||||
|---|---|---|---|---|---|---|
| Local Recurrence | Nodal Metastasis | Disease-Specific Death | Disease-Specific Death in Localized cSCC at Presentation | |||
| Risk Ratio (95% CI) | Risk Ratio (95% CI) | Included Studies | Risk Ratio (95% CI) | Included Studies | Risk Ratio (95% CI) | |
| Poor differentiation | 2.66 (1.72–4.14) | 4.98 (3.30–7.49) | Brinkman et al. [16] Friedman et al. [17] Karia et al. [7] Kyrgidis et al. [18] |
5.65 (1.76–18.20) | Brinkman et al. [16] Eigentler et al. [19] Karia et al. [7] Ruiz et al. [20] |
3.72 (0.80–17.28) |
| Depth beyond fat | 7.61 (4.17–13.88) | 11.21 (3.59–34.97) | Clayman et al. [21] Friedman et al. [17] Karia et al. [7] Kyrgidis et al. [18] |
4.49 (2.05–9.82) | Conde-Ferreiros et al. [22] Karia et al. [7] Ruiz et al. [20] |
2.24 (0.34–14.75) |
| Diameter 20 mm or more | 3.22 (1.91–5.45) | 6.15 (3.56–10.65) | Karia et al. [7] | 19.10 (5.80–62.95) | Karia et al. [7] Ruiz et al. [20] |
4.57 (0.20–106.66) |
| PNI present | 4.30 (2.80–6.60) | 2.95 (2.31–3.75) | Clayman et al. [21] Kyrgidis et al. [18] Schmults et al. [23] |
4.06 (3.10–5.32) | Schmults et al. [23] Ruiz et al. [20] |
1.63 (0.21–12.88) |
| Thickness ≥ 6 mm | 7.13 (3.04–16.72) | 6.93 (4.02–11.94) | - | - | Conde-Ferreiros et al. [22] Eigentler et al. [19] |
2.44 (0.30–19.66) |
| Thickness (continuous) | - | - | - | - | Tschetter et al. [24] | 1.20 (1.00–1.44) |
| Thickness > 2 mm | 9.64 (1.30–71.52) | 10.76 (2.55–45.31) | - | - | - | - |
| Location ear | 1.28 (0.56–2.90) | 2.33 (1.67–3.23) | Griffiths et al. [25] Schmults et al. [23] |
4.67 (1.28–17.12) | Eigentler et al. [19] Griffiths et al. [25] Schmults et al. [23] |
1.71 (0.61–4.78) |
| Location lip | 1.28 (0.56–2.90) | 2.28 (1.54–3.37) | - | 4.55 (1.41–14.69) | - | - |
| Location head/neck | - | - | - | - | Schmults et al. [23] Ruiz et al. [20] |
0.98 (0.29–3.24) |
| Location temple | 3.20 (1.12–9.15) | 2.82 (1.72–4.63) | - | 1.80 (0.22–14.79) | - | - |
| Immunosuppression | 1.51 (0.81–2.81) | 1.59 (1.07–2.37) | Karia et al. [7] | 0.35 (0.05–2.58) | Eigentler et al. [19] Karia et al [7] Ruiz et al. [20] Tam et al. [26] |
1.85 (1.32–2.61) |
-: not reported. Statistically significant risk ratios are shown in bold.