Table 3.
Preclinical studies on the prenatal HSD consumption on behavioural and molecular or neurochemical consequences after drugs of abuse in offspring.
| Prenatal Exposure | Animals | Drug of Abuse | Consequences Enhanced by HSD | Ref | ||
|---|---|---|---|---|---|---|
| HSD Model | Period | Behavioural | Molecular/Neurochemical | |||
| 70% carbohydrates (44% sucrose) | Pregnancy and lactation | Female WR offspring | Cocaine hydrochloride | ↑ CUE- and cocaine reinstatement relapse in cocaine SA ↑ cocaine-seeking behaviour |
↑ MC4R expression in the NAc, and dorsal striatum | [130] |
| Male WR offspring | ↓ MC4R expression in the PFC, NAc, and dorsal striatum ↑ MC4R expression in the amygdala |
[131] | ||||
| 10% sucrose or 16% HFCS solution | Male and female SD offspring | Amphetamine | ↑ female alcohol intake during alcohol training ↑ male hyperactivity in LAM |
- | [199] | |
HSD: High-Sugar Diet; HFCS: high-fructose corn syrup; WR: Wistar rat strain; SD: Sprague Dawley rat strain; CUE: tone + light—conditional stimulus; SA: self-administration; LAM: locomotor activity measurement; NAc: nucleus accumbens; PFC: prefrontal cortex; MC4R: melanocortin 4 receptor; ↓: decrease; ↑: increase; -: no data.