Table 4.
APOE genotype and allele frequencies in patients with ON and controls grouped by gender.
| Genotype, Allele | Males | p-Value | Females | p-Value | ||
|---|---|---|---|---|---|---|
| ON (n = 31) | Control (n = 307) | ON (n = 56) | Control (n = 276) | |||
| APOE ε2/ε2, n (%) | 0 (0) | 1 (0.3) | - | 0 (0) | 1 (0.3) | - |
| APOE ε2/ε3, n (%) | 7 (22.6) | 48 (15.6) | 0.318 | 7 (12.5) | 48 (15.6) | 0.547 |
| APOE ε2/ε4, n (%) | 1 (3.2) | 8 (2.6) | 0.838 | 0 (0) | 8 (2.6) | - |
| APOE ε3/ε3, n (%) | 15 (48.4) | 204 (66.4) | 0.045 | 42 (75.0) | 204 (66.4) | 0.208 |
| APOE ε3/ε4, n (%) | 8 (25.8) | 43 (14.0) | 0.080 | 7 (12.5) | 43 (14.0) | 0.764 |
| APOE ε4/ε4, n (%) | 0 (0) | 3 (1.0) | - | 0 (0) | 3 (1.0) | - |
| ε2 allele, n (%) | 8 (12.9) | 58 (9.4) | 0.382 | 7 (6.25) | 58 (9.4) | 0.276 |
| ε3 allele, n (%) | 45 (72.6) | 499 (81.3) | 0.100 | 98 (87.5) | 499 (81.3) | 0.113 |
| ε4 allele, n (%) | 9 (14.5) | 57 (9.3) | 0.186 | 7 (3.25) | 57 (9.3) | 0.298 |