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. 2022 Jul 15;23(14):7814. doi: 10.3390/ijms23147814

Figure 5.

Figure 5

Unkeito (UKT) induces mononuclear osteoclast apoptosis via caspase-3 activation. (a) caspase-3 and (b) annexin-v mRNA expression in the early stage of apoptosis, normalized to that of Gapdh; (c) cleaved caspase-3 abundance detected via immunocytochemistry (n = 3; scale bar = 10 µm); (d) the percentages of cleaved caspase-3 positive in total of tartaric acid resistant phosphatase (TRAP) -positive cells. Error bars represent ± standard error of the mean. * p < 0.05; ** p < 0.01, **** p < 0.0001, versus negative control groups (PBS without RANKL); ND: not detected.