Figure 6.

Ex vivo fluorescent imaging of the human BCa lumpectomy tissue sample. (A)—Color photo of the surface of the fresh cut of the human lumpectomy sample. Red asterisk indicates a blood clot. (B)—Image of 6QC-induced cathepsin-dependent ICG-fluorescence of the sample surface after topical application of AKRO-QC-ICG imaging gel (800 nm). The red dotted circle shows a high fluorescent ICG signal that corresponds to the tumor region of the sample. (C)—H&E histology of the sample at low magnification. Blue line and black arrows represent the tumor area. Notes: red arrows indicate spots of the yellow pathological ink in (A) and non-specific fluorescence in (B) on the surface and edge of the sample. Imaging—Pearl Trilogy Imaging System.