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. 2022 Apr 26;20(7):1535–1549. doi: 10.1111/jth.15734

FIGURE 1.

FIGURE 1

Platelet mechanisms in hemostasis involving platelet adhesion to von Willebrand Factor (vWF) and collgen, aggregation mediated by fibrinogen (Fg), coagulation amplification via surface presentation of phosphatidylserine (PS) to render the ‘thrombin burst’ for localized generation of fibrin from fibronogen, and secretion of granule contents to augment coagulation kinetics and fibrin morphology; Platelets and fibrin form the hemostatic clot to stop bleeding