Figure 21.

RA CD8⁺ Temra differentially expressed genes in the PI3K-AKT pathway and the mTOR pathway. Red up arrows indicate upregulation. Red arrows indicate the effect of the differentially regulated genes on their targets, where T shaped arrows indicate inhibition and normal arrows indicate activation. Dotted arrows indicate the presence of intermediate steps between the two connected proteins. Red crosses show the interactions that are lost in the RA CD8⁺ Temra cells due to inhibition or downregulation of the upstream proteins.