Table 14.
Number of nodes and edges in the GTRD-annotated transcription factor–target gene network of untreated RA and treated RA T cell subsets.
| Cell Type | RA Untreated vs. Healthy | IFX Treated vs. RA Untreated | MTX Treated vs. RA Untreated | TCZ Treated vs. RA Untreated | ||||
|---|---|---|---|---|---|---|---|---|
| Total Nodes, TFs, Target Genes | Total Edges | Total Nodes, TFs, Target Genes | Total Edges | Total Nodes, TFs, Target Genes | Total Edges | Total Nodes, TFs, Target Genes | Total Edges | |
| CD4+ Tn | 92, 88, 4 | 127 | 650, 624, 26 | 1160 | 23, 23, 0 | 24 | 131, 123, 8 | 196 |
| CD4+ Tcm | 7, 7, 0 | 5 | 0 | 0 | 0 | 0 | 207, 202, 5 | 257 |
| CD4+ Tem | 627, 592, 35 | 1244 | 766, 728, 38 | 1767 | 588, 560, 28 | 978 | 1035, 984, 51 | 4205 |
| CD8+ Tn | 1173, 1115, 58 | 12,329 | 1074, 1020, 54 | 6475 | 1136, 1076, 60 | 12,321 | 1183, 1123, 60 | 8528 |
| CD8+ Tcm | 1072, 1018, 54 | 7874 | 182, 176, 6 | 234 | 438, 420, 18 | 1470 | 31, 31, 0 | 32 |
| CD8+ Tem | 1211, 1149, 62 | 15,411 | 1136, 1077, 59 | 8197 | 1248, 1183, 65 | 15,138 | 1146, 1092, 54 | 9149 |
| CD8+ Temra | 1285, 1214, 71 | 75,606 | 1279, 1211, 68 | 53,945 | 1281, 1211, 70 | 48,879 | 1284, 1215, 69 | 45,443 |