Table 16.

Top ten target genes in GTRD- and GeneHancer-annotated transcription factor–target gene network of untreated RA CD8⁺ Tem cells.

Rank	Top Ten GTRD-Annotated Glycolysis Genes by In-Degree					Top Ten GeneHancer-Annotated Glycolysis Genes by In-Degree
	Gene	DE	In-Degree in GTRD	In-Degree in GeneHancer	Common Edges *	Gene	DE	In-Degree in GTRD	In-Degree in GeneHancer	Common Edges *
1	PFKFB3	DOWN	103	79	53	FBP2	-	11	103	5
2	GAPDH	UP	60	36	21	PFKFB3	DOWN	103	79	53
3	BPGM	-	40	18	9	DLD	DOWN	39	36	20
4	DLD	DOWN	39	36	20	GAPDH	UP	60	36	21
5	G6PD	-	38	22	17	ALDOB	-	4	33	2
6	SLC2A1	-	31	24	14	G6PC2	-	3	24	1
7	PDHA1	-	25	13	10	SLC2A1	-	31	24	14
8	PGAM1	-	18	11	7	G6PC	-	12	22	9
9	AKR1A1	-	14	10	8	G6PD	-	38	22	17
10	G6PC	-	12	22	9	HKDC1	-	6	19	4

* Common edges refer to the number of TF—target edges for a particular glycolysis gene that is annotated by both databases.