Table 18.
Differential expression of regulators of glycolysis in untreated RA CD8+ Tem cells. Means are calculated from DESeq2 normalized counts.
| Gene | adj. Pval | Log2FC | Linear FC | RA Mean | Control Mean |
|---|---|---|---|---|---|
| IRS2 | 0.072 | −1.268 | 0.415 | 40.38 | 97.49 |
| RUNX3 | 0.063 | −0.617 | 0.652 | 2925.192 | 4511.98 |
| ELOB | 0.003 | 1.766 | 3.401 | 2695.83 | 785.48 |
| EGLN3 | 0.073 | 1.616 | 3.064 | 27.06 | 8.55 |
| PFKFB3 | 0.00097 | −1.462 | 0.363 | 112.33 | 310.92 |
| PFKFB4 | 0.042 | 1.611 | 3.054 | 18.22 | 5.88 |
CD8+ Tem cells from infliximab-treated individuals and methotrexate-treated individuals did not have any differentially expressed glycolysis-related genes when compared with untreated RA individuals. None of the transcription factors with high centrality scores were differentially expressed in either network.