Table 19.

Top ten target genes in GTRD- and GeneHancer-annotated transcription factor–target gene network of untreated RA CD8⁺ Tem cells.

Rank	Top Ten GTRD-Annotated Glycolysis Genes by In-Degree					Top Ten GeneHancer-Annotated Nodes by In-Degree
	Gene	DE	In-Degree in GTRD	In-Degree in GeneHancer	Common Edges	Gene	DE	In-Degree in GTRD	In-Degree in GeneHancer	Common Edges
1	ENO1	-	189	135	88	ENO1	-	189	135	88
2	G6PC3	-	182	124	88	G6PC3	-	182	124	88
3	ALDOC	-	173	59	28	G6PC2	-	11	120	4
4	SLC2A1	-	155	118	77	AKR1A1	-	129	119	65
5	ENO3	UP	150	106	76	SLC2A1	-	155	118	77
6	PDHA1	UP	147	72	43	ADH7	-	60	109	17
7	ACSS2	-	146	104	71	HK2	UP	144	109	57
8	HK2	UP	144	109	57	ENO3	UP	150	106	76
9	AKR1A1	-	129	119	65	HK1	-	124	106	62
10	HK1	-	124	106	62	ACSS2	-	146	104	71