Table 1.
Irradiation conditions. The dose in each BNCT protocol was prescribed to precancerous tissue, the dose-limiting tissue. * Components of background dose; ** Total background dose.
| Dose Components | Fast Neutrons * | Gamma Photons * | Induced Protons * | Total Dose Without Boron Irradiation Component ** | Boron Irradiation Component | Boron Dose/ppm Boron Concentration | Total Absorbed Dose |
|---|---|---|---|---|---|---|---|
| MID:BSA/BNCT 15 mg/kg 19 h post-injection-4.8 Gy absorbed dose to precancerous tissue | |||||||
| Tumor | - | 0.44 ± 0.04 Gy | 0.60 ± 0.13 Gy | 1.05 ± 0.14 Gy | 4.9 ± 2.0 Gy | 0.16 ± 0.08 Gy | 6.0 ± 2.0 Gy |
| Precancerous tissue | - | 0.44 ± 0.04 Gy | 0.60 ± 0.13 Gy | 1.05 ± 0.14 Gy | 3.8 ± 1.9 Gy | 0.16 ± 0.11 Gy | 4.8 ± 1.9 Gy |
| Normal tissue | - | 0.44 ± 0.04 Gy | 0.60 ± 0.13 Gy | 1.05 ± 0.14 Gy | 1.1 ± 0.3 Gy | 0.16 ± 0.06 Gy | 2.1 ± 0.4 Gy |
| MID:BSA/BNCT 15 mg/kg 19 h post-injection-6.0 Gy absorbed dose to precancerous tissue | |||||||
| Tumor | - | 0.55 ± 0.06 Gy | 0.74 ± 0.16 Gy | 1.30 ± 0.17 Gy | 6.1 ± 2.5 Gy | 0.19 ± 0.10 Gy | 7.4 ± 2.5 Gy |
| Precancerous tissue | - | 0.55 ± 0.06 Gy | 0.74 ± 0.16 Gy | 1.30 ± 0.17 Gy | 4.7 ± 2.4 Gy | 0.19 ± 0.13 Gy | 6.0 ± 2.4 Gy |
| Normal tissue | - | 0.55 ± 0.06 Gy | 0.74 ± 0.16 Gy | 1.30 ± 0.17 Gy | 1.3 ± 0.4 Gy | 0.19 ± 0.07 Gy | 2.6 ± 0.4 Gy |
| MID:BSA/BNCT 15 mg/kg 19 h post-injection-7.5 Gy absorbed dose to precancerous tissue | |||||||
| Tumor | - | 0.67 ± 0.07 Gy | 0.93 ± 0.20 Gy | 1.60 ± 0.21 Gy | 7.7 ± 3.1 Gy | 0.24 ± 0.13 Gy | 9.3 ± 3.2 Gy |
| Precancerous tissue | - | 0.67 ± 0.07 Gy | 0.93 ± 0.20 Gy | 1.60 ± 0.21 Gy | 5.9 ± 3.0 Gy | 0.24 ± 0.17 Gy | 7.5 ± 3.0 Gy |
| Normal tissue | - | 0.67 ± 0.07 Gy | 0.93 ± 0.20 Gy | 1.60 ± 0.21 Gy | 1.6 ± 0.5 Gy | 0.24 ± 0.09 Gy | 3.2 ± 0.5 Gy |