Table 1.

Major substances shared by NETs and EVs/ENDs upon stimulation with various priming or activating agents.

Neutrophil Stimulus Used in Study		Substance Detected with Both NETs and EVs/ENDs	References
EVs/ENDs	NETs
		Granule proteins/peptides
A. fumigatus conidia	PMA	Azurocidin	[14,45,46,47]
A. fumigatus conidia	A23187	Cathelicidin antimicrobial peptide	[14,47]
fMLP	MSU, PMA, IL-8, LPS	Cathepsin G	[8,33,45,46,48]
A. fumigatus conidia	A23187	Cysteine-rich secretory protein 3	[14,47]
A. fumigatus conidia	TNF-α	Defensins	[47,49]
fMLP, Ionomycin	PMA, IL-8, LPS	Neutrophil Elastase	[1,45,46,50,51]
fMLP, Ionomycin	MSU, PMA, TNF-α, IL-8, LPS	Lactoferrin	[1,33,45,46,48,49,51]
A. fumigatus conidia	A23187	Lipocalin	[14,47]
A. fumigatus conidia	PMA	Lysozyme C	[46,47]
fMLP, Ionomycin	A23187	Matrix metallopeptidases	[14,50,51]
fMLP, PMA, Ionomycin	MSU, PMA, TNF-α, IL-8, LPS	Myeloperoxidase	[1,8,33,45,46,48,49,51,52]
fMLP	PMA	Proteinase-3	[45,50]
		DAMPs
Not cell type or stimulus-specific	PMA, IL-8, LPS	DNA	[1,53]
fMLP	MSU, PMA, TNF-α	Histones	[14,33,45,46,48,49]
PMA	PMA	HMGB-1	[40,54]
fMLP	PMA, IL-8, amyloid fibrils, Leishmania promastigotes	microRNA	[55,56]
fMLP	PMA, TNF-α,	S100 family proteins	[31,33,45,46,49]
	PMA
		Cytoskeleton proteins
fMLP	MSU, TNF-α	Myosin-9	[33,46,48,49]
fMLP	MSU, PMA	Actins	[33,46,48]
fMLP	A23187, MSU, PMA	α-Enolase	[14,31,48]
fMLP, pneumolysin	MSU, PMA	Annexins	[14,33,48,57,58]
fMLP	Rheumatoid Factor	Catalase	[33,59]
fMLP	PMA, TNF-α plus ANCA	Complement components	[33,60,61]
fMLP, LPS	A23187	Cytokines/Chemokines	[14,35,62,63]
fMLP	PMA	Gelsolin	[33,46]
fMLP	Plasma from stroke patients	Phosphatidylserine	[64,65]
Autoimmune vasculitis	Autoimmune vasculitis; deep vein thrombosis; viral infection	Tissue Factor	[66,67,68]