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. 2022 Jul 9;58(7):912. doi: 10.3390/medicina58070912

Table 1.

Preclinical studies evaluating the use of acellular fish skin in burn wounds.

Study Acellular
Fish Skin		 Comparison
Product		 Animal Model Scalding
Conditions		 Treatment
Period		 Endpoints Main
Findings
Accelerated Wound
Closure of Deep Partial
Thickness Burns with
Acellular Fish Skin Graft.
(Stone II et al., 2021) [2]		 North
Atlantic cod (Kerecis® Omega3)		 Fetal bovine
dermis
(Primatrix TM)		 6 female Yorkshire pigs
of weights 51.8 ± 3.3 kg
at the time of the burn wound creation		 Creation of ten 5 cm × 5 cm wounds (4 DPT and 6 FT) with a thermocouple brass burn device by Alam et al. [3] heated to 100 °C.
  • -

    Applied pressure: 4000 g/cm2

  • -

    Contact time: DPT: 25 s FT: 30 s

 60 days Reepithelialization time, skin function (skin moisture
properties,
microcirculation)		 AFS: faster reepithelialization time in DPT and FT wounds.
A comparative study of
two porous sponge scaffolds prepared by collagen
derived from porcine skin
and fish scales as burn wound
dressings in a rabbit model.
(Shi et al., 2020) [4]		 Grass carp Porcine skin-derived
Collagen, dry gauze, Vaseline gauze		 2 New Zealand white rabbits Creation of ten 2 cm × 2 cm wounds with 35 layers of boiled gauze which was
applied with gravitational pressure.
  • -

    Contact time: 20 s

 28 days Wound size,
dressing properties		 AFS: faster wound healing after 12 days, higher moisture permeability
Marine Collagen Peptides from the skin of Nile
Tilapia (Oreochromis
niloticus): Characterization and Wound Healing
Evaluation.
(Hu et al., 2017) [5]		 Nile Tilapia - 48 New Zealand
white rabbits		 Creation of one DPT 4 × 4 cm burn wound with a scalding device (YLS-5Q, Bejing, China) heated to 100 °C.
  • -

    Applied pressure: 1000 g

  • -

    Contact time: 5 s

 18 days Reepithelialization time, histological analysis of the skin structure integrity, cell types and granulation tissue AFS: faster reepithelialization time in comparison to the control group.
Reduction of inflammation and promotion of granulation tissue formation

Abbreviations: acellular fish skin (AFS); deep partial-thickness (DPT); full thickness (FT), seconds (s).