Table 2.

Two-sample and multivariable Mendelian randomization estimates of the effects of systolic and diastolic blood pressure on the outcomes. MR, Mendelian randomization; SBP, systolic blood pressure; DBP, diastolic blood pressure; AF, atrial fibrillation; HF, heart failure; T2DM, type 2 diabetes; CAD, coronary artery disease; MI, myocardial infarction; CKD, chronic kidney disease. * SBP-exclusive SNPs. ** DBP-exclusive SNPs. § SBP-excusive SNPs and DBP-exclusive SNPs.

	Two-Sample MR				Multivariable MR
	SBP_Excl (SBP) *		DBP_Excl (DBP) **		SBPexc+DBPexc (SBP) §		SBPexc+DBPexc (DBP) §
	Estimates	p-Value	Estimates	p-Value	Estimate	p-Value	Estimate	p-Value
AF	0.0247	8.11 × 10−6	0.0104	0.3872	0.0244	0.0007	−0.0347	0.8853
HF	0.0341	2.17 × 10−5	−0.003	0.8529	0.0516	0.0003	−0.1297	0.3470
T2DM	0.0252	0.0001	0.0162	0.3297	0.0260	0.0003	−0.0151	0.7266
CAD	0.0172	0.0148	0.0347	0.0453	0.0238	0.0116	−0.0162	0.5542
Stroke	0.0365	3.03 × 10−9	0.0375	0.0047	0.0398	1.17 × 10−5	0.0195	0.3034
Ischemic stroke	0.0396	4.07 × 10−9	0.0431	0.0009	0.0418	1.85 × 10−6	0.0250	0.2854
Ischemic stroke small-vessel	0.0181	0.0553	0.06	0.0034	0.0108	0.1585	0.0484	0.1559
MI	0.0079	0.2816	0.0341	0.0520	0.0117	0.3364	0.0096	0.1249
CKD	0.0111	0.2045	0.0118	0.6163	0.0219	0.2598	−0.0226	0.9621