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. 2022 Jul 1;15(7):820. doi: 10.3390/ph15070820

Scheme 2.

Scheme 2

Synthesis of O-alkyl, O-aryl, and S-aryl derivatives 79. Reagents and conditions: (i) R2ONa, R2OH, 60 °C, 6–22 h; (ii) R3-PhOH, K2CO3, DMF, 130 °C, 3 h; (iii) R3-PhSH, K2CO3, DMF, 1 h 30, 30 °C.