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. 2022 Jul 10;11(14):2160. doi: 10.3390/cells11142160

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hallmark analysis demonstrated the alteration of multiple pathways in SK-UT-1 cells in response to TP-472 treatment. (A) Functional pathways analysis identified significantly altered pathways in SK-UT-1 cells treated with TP-472. Significantly enriched gene sets (TP-472 vs. control) from GSEA using Hallmark biological processes in MSigDB. Gene count and significance levels are shown by the size and color of each circle, respectively. Pathways analysis revealed that several gene sets associated with TNF-a signaling via NFkB (B), KRAS signaling (C), MYC targets (D), MTORC1 signaling (E), and interferon-alpha response (F) were altered.