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. 2022 Jul 10;11(14):2160. doi: 10.3390/cells11142160

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Network representation of the modular pattern of gene expression during the transition of control to TP-472 treatment. (A) Flowchart of modular pattern analysis, (B) Left: Nine network modules are color coded. Middle and right: Overlay of gene expression z-scores for all genes in the control and TP-472 conditions shown in blue (low) to red (high) z-score color scale. Four constructed modules, including mitotic cell cycle phase (GO: 0044772), regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028), apoptotic process (GO: 9996915), and translational termination (GO: 0006415) were enriched and highlighted. Note: Greek numerals are the index for Modules.