Table 4.
The significant terms of the modules based on the 9 different enrichment databases.
| Module | Mid Night Blue | Yellow | Cyan | Dark Green |
|---|---|---|---|---|
| GO_Biological_Process_2021 | Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028) (1.38 × 10−5) | Apoptotic process (GO:0006915) (2.00 × 10−5) |
Translational termination (GO:0006415) (8.54 × 10−31) | Mitotic cell cycle phase transition (GO:0044772) (3.36 × 10−7) |
| MSigDB_Hallmark_2020 | TNF-alpha Signaling via NF-kB (0.000138704) | TNF-alpha Signaling via NF-kB (1.08 × 10−16) | Myc Targets V1 (1.25 × 10−39) | PI3K/AKT/mTOR Signaling (0.031214077) |
| WikiPathway_2021 | MAPK Signaling Pathway WP382 (0.001957412) | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways WP706 (0.000455634) |
G1 to S cell cycle control WP45 (0.037948453) | Cell cycle WP179 (1.90 × 10−5) |
| Reactome_2015 | TRAF6-mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Homo sapiens R-HSA-975138 (0.093688577) | MAPK family signaling cascades Homo sapiens R-HSA-5683057 (0.019875184) | Cyclin E associated events during G1/S transition Homo sapiens R-HSA-69202 (9.09 × 10−10) | Cell Cycle Homo sapiens R-HSA-1640170 (3.50 × 10−11) |
| ENCODE_Histone_Modifications_2015 | H3K4me1 (2.98 × 10−15) |
H3K27me3 (4.96 × 10−48) |
H3K4me3 (5.19 × 10−10) |
H3K4me3 (1.91 × 10−6) |
| TargetScan_microRNA_2017 | hsa-miR-4776-5p MicroRNAs (0.001954789) | hsa-miR-4727-3p (0.001242581) |
hsa-miR-1284 (0.021500132) |
hsa-miR-3682-3p MicroRNAs (5.49 × 10−14) |
| InterPro_Domains_2019 | NFkappaB IPT domain (0.007433747) | Death domain (0.001693697) | LSM domain (1.28 × 10−9) | Protein kinase domain (4.49 × 10−5) |
| Pfam_Domains_2019 | Pkinase (0.000212328) | Death (0.000791274) | LSM (5.50 × 10−10) |
Pkinase (3.62 × 10−5) |
| Jensen_COMPARTMENTS | Neuron part (5.89 × 10−7) | BCL-2 complex (3.34 × 10−8) | Intracellular ribonucleoprotein complex (5.21 × 10−49) | Cellular component (5.48 × 10−22) |