Table 1.

MIC₅₀, MIC₉₀, ECOFF, and breakpoint values (mg/L) for isavuconazole and comparators.

Study, Species (Number of Isolates Tested)	Isavuconazole		Voriconazole		Posaconazole
	MIC50, MIC90	ECOFF/R Breakpoint According to EUCAST v. 10.0 2020	MIC50, MIC90	ECOFF/R Breakpoint According to EUCAST v. 10.0 2020	MIC50, MIC90	ECOFF/R Breakpoint According to EUCAST v. 10.0 2020
Pfaller et al., 2021 [23]
A. fumigatus ISA (n = 70), VORI (n = 189), POSA (n = 189)	0.5, 1	2/>2	0.5, 0.5	1/>1	0.25, 0.5	0.25/>0.25
A. flavus ISA (n = 19), VORI (n = 43), POSA (n = 43)	0.5, 1	2/>2	0.5, 1	2/-	0.25, 0.5	0.5/-
A. niger ISA (n = 18), VORI (n = 46), POSA (n = 46)	0.5, 4	4/-	1, 1	2/-	0.5, 1	0.5/-
A. terreus ISA (n = 6), VORI (n = 14), POSA (n = 14)	2, ND	1/>2	0.25, 0.25	2/-	0.25, 0.25	0.25/>0.25
A. nidulans ISA (n = 6), VORI (n = 11), POSA (n = 11)	0.03, ND	0.25/>0.25	0.12, 0.25	1/>1	0.25, 0.5	0.5/-
Astvad et al., 2017 [22]
A. fumigatus (n = 211)	1, ND	2/>2	0.5, ND	1/>1	ND	0.25 > 0.25
A. niger (n = 41)	2, ND	4/-	1, ND	2/-	ND	0.5/ND
A. terreus species complex (n = 27)	1, ND	1/>2	1, ND	2/-	ND	0.25/>0.25
A. flavus species complex (n = 19)	1, ND	2/>2	1, ND	2/-	ND	0.5/-

Abbreviations: ECOFFs, epidemiologic cut-off value; EUCAST, European Committee on Antimicrobial Susceptibility Testing; MIC₅₀, Minimum Inhibitory Concentration required to inhibit the growth of 50% of organisms; MIC₉₀, Minimum Inhibitory Concentration required to inhibit the growth of 90% of organisms; ISA, isavuconazole; ND, no data; POSA, posaconazole; VORI, voriconazole; -, not defined.