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. 2022 Jul 11;14(7):1449. doi: 10.3390/pharmaceutics14071449

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A–E) Histopathological images of rat bone at the area of the tibial joint (10× magnification). (A) Sham control displaying regular trabecular construction (Indicated by arrows). (B) OVX control displaying the damage of interconnectivity, diminishing trabecular construction and lytic variations (Indicated by arrows). (C) Raloxifene group shows rebuilding of normal trabecular construction of bones (Indicated by arrows). (D) Naringenin plain also causes restoration of trabecular spaces (Indicated by arrows). (E) NRG-NS shows bone renewal (Indicated by arrows).