Figure 1.

Immune cell-specific targeting by both endogenous and exogenous GC. Various immune cell types were experimentally targeted for GR deletion and then tested in animal models of infection and inflammation for actions by either endogenously released GC (left panel) or exogenous treatment with GC (right panel), or both. Disease models that are affected by impaired GR signaling in a certain immune cell type are indicated as green boxes in the central ovals. Animal models of disease not affected by impaired GR signaling in particular cells are depicted as boxes bordered by dashed lines. Cell type-specific regulation of inflammation and immunity by GC is seen, for example, in Ag-induced arthritis where T cells, but not B cells or myeloid cells, are targeted by GC (right panel). The red arrow means: ‘increased’ or ‘enhanced’. Created with BioRender.com (accessed on 24 April 2022).