Figure 1.

Pre-treatment with UCC118^TM reduces severity of disease in a DSS-induced colitis model. C57BL/6JOlaHsd mice were pre-treated with 100 μL UCC118™ (10⁹ CFU/mouse) or sterile PBS by oral gavage daily. On day 7, mice were treated with 2.5% dextran sulphate–sodium via drinking water ad libitum for 6 days. Mice were weighed daily (A) and stool was checked for occult blood (B) and diarrhoea (C). Disease activity index (DAI, D) was plotted as an average of weight score, blood score and stool score on a scale of 0–4. Representative results of two independent experiments. Statistical analysis performed by two-way ANOVA. Stars indicate statistical significance in comparisons between PBS + DSS and UCC118 + DSS groups. ** p < 0.01, * p < 0.05. n = 4 mice per group.