Figure 5.

IR825 dye as a photothermal conversion agent. (A) Schematic illustration showing the structure and action mechanism of NIR-absorptive DOX-loaded stealth liposome; (B) heating curves of the hydration solution (5% dextrose) and the NSL solution upon continuous NIR laser illumination at a laser power density of 0.5 W·cm⁻²; (C) DOX release profiles of DOX-loaded NSL at physiological temperature and under NIR light irradiation (power density: 0.5 W·cm⁻²), respectively. Relative viabilities of HeLa cells incubated with (D) nonloaded NSL and (E) DOX-loaded NSL at various concentrations without and with NIR laser illumination for 5 and 10 min, respectively; (F) confocal laser fluorescence spectroscopy images of live HeLa cells incubated with free DOX (3 μg·mL⁻¹) or DOX-loaded NSL (200 μg·mL⁻¹) solutions. The cell nuclei were stained with H33258. Scale bar is 10 μm. Reproduced with permission from ref. [106] Copyright (2015). Wiley-VCH Verlag.