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. 2022 Jul 19;23(14):7935. doi: 10.3390/ijms23147935

Table 1.

Similarities among lower activity or synthesis of XO, AO, SUOX, and Moco or Mo deficiency and symptoms of Alzheimer’s disease.

Lower Activity or Synthesis of XO, AO, SUOX or Moco, or Mo Deficiency Alzheimer’s Disease
Similarities
Sulfate Low urinary SO42− content [9,10].

  1. High Cys/SO42− in blood plasma [7];

  2. AD’s plasma had only 22% SO42− than standard control [7].
Methionine High plasma Met [105].

  1. Alterations in pathways related to Met metabolism [106];

  2. Serum levels of Met-SO are higher in early-stage AD as compared with MCI patients [53].
Cysteine Sulfite loading stops the conversion of Met to Cys, and this causes Cys levels to fall [105].

  1. Cys content decreased inside brain cells [60];

  2. Cys is high in brain AD [58].
Uric acid Serum and urinary uric acid
contents are reduced [107].

  1. Lower contents of uric acid in AD patients than healthy controls [87];

  2. Patients with gout with elevated uric acid contents in the blood may have decreased risk for AD [89].