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. 2022 Jul 19;23(14):7935. doi: 10.3390/ijms23147935

Table 3.

Similarities between Cu and Mo contents in Alzheimer’s disease (AD).

Serum Levels Brain Tissue Levels
Similarities
Cu High content of nCp–Cu in serum [36]. In brain tissues, the Cu content is usually low [36,68].
Evidence suggesting a low level of Mo in AD brain tissues:
Mo Serum Mo content increased progressively,
passing from healthy subjects (HS) through subjective memory complaint, mild cognitive
impairment up to AD, and the difference between HS and AD was statistically significant [124].

  1. High serum uric acid contents were significantly associated with decreased risk of AD, so patients with gout may have decreased risk for AD [87,89];

  2. Brain tissues from AD patients/models demonstrate reductions in adenylyl cyclase activity [102,103].