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Toyocamycin is a potent and specific inhibitor of CDK9. Enzymatic assays were performed with toyocamycin at different concentrations against (A) CDK9/CyclinT1, (B) CDK7/Cyclin H/MAT1, (C) CDK2/Cyclin 2A, (D) CDK4/Cyclin D3, and (E) CDK6/Cyclin D3. Concentration producing 50% enzymatic inhibition (IC50) was calculated for toyocamycin and other inhibitors listed in the graphs.
