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. 2022 Jul 19;27(14):4601. doi: 10.3390/molecules27144601

Figure 5.

Figure 5

Protopine PMA-stimulated MAPK activity in HepG2 cells. (A) Levels of MAPK expression determined by Western blot. (B) ERK1/2 activated by PMA inhibited its activation in a concentration-dependent manner on protopine. (C) Protopine inhibited JNK activation in a concentration-dependent manner. (D) Protopine suppressed the activity of p38 to a high level when treated with 40 µM. The results are presented as mean ± SD. # p < 0.05 ## p < 0.01, and ### p < 0.001 indicate significant differences from the control group. * p < 0.05, ** p < 0.01, indicating a significant difference from the PMA group.