Table 2.

Anticancer activity of seagrasses.

Species	Extract/Active Compound	Cell Line	Inhibition	References
C. serrulata	AgNPs (silver nanoparticles)	HeLa	IC50: 34.5 µg/mL	[26]
	Aqueous extract	HeLa	IC50: 107.7 µg/mL	[26]
H. stipulacea	Ethyl acetate extract (leaves)	MG63	IC50: 29.4 μg/mL	[21]
		SHSY5Y	IC50: 10.6 μg/mL	[21]
	Ethyl acetate extract (stems)	MG63	IC50: 19.1 μg/mL	[21]
		SHSY5Y	IC50: 18.7 μg/mL	[21]
	Hexane extract (leaves)	HCT116	IC50: 19.5 μg/mL	[21]
	Hexane extract (stems)	HCT116	IC50: 7.6 μg/mL	[21]
P. oceanica	EtOH/H2O (7:3)	SH-SY5Y	Inhibits 57% cell migration at 3 μg/mL after 7 h treatment	[33]
	Hydrophilic extract	HT1080	Inhibits 72.3% cell migration after 12 h treatment	[27]
	MeOH/H2O 7:3 (balls extract)	HepG2	IC50: 24.3 µg/mL	[25]
		MCF7	IC50: 22.6 µg/mL	[25]
		HCT116	IC50: 22.5 µg/mL	[25]
	MeOH/H2O 7:3 (leaves extract)	HepG2	IC50: 17 µg/mL	[25]
		HepG2	IC50: 28.3 µg/mL	[25]
		HCT116	IC50: 27.8 µg/mL	[25]
S. filiforme	Chloroform fraction of hydroethanolic extract	A549	Decreases the viability of A549 cells below 60% at 100 µg/mL	[34]
T. ciliatum	Methanolic extract	HCT-116	IC50: 4.2 μg/mL	[17]
		HeLa	IC50: 9.8 μg/mL	[17]
		HepG2	IC50: 8.12 μg/mL	[17]
		MCF7	IC50: 4.12 μg/mL	[17]
T. testudinum	Chloroform fraction of the hydroethanolic extract	A549	IC50: 20.4 µg/mL	[28]
		EA.hy926	IC50: 248.4 µg/mL	[28]
	Hydroethanolic extract	RKO	IC50: 174.9 µg/mL	[29]
		SW480	IC50: 58.9 µg/mL	[29]
		CT26	IC50: 115.3 µg/mL	[29]
		HepG2	IC50: 102 μg/mL	[30]
		PC12	IC50: 135 μg/mL	[30]
		Caco2	IC50: 165 μg/mL	[30]
		4T1	IC50: 129 μg/mL	[30]
	Polyphenol fraction of hydroethanolic extract	HCT15	IC50: 22.47 µg/mL	[23]
		HT29	IC50: 93.11 µg/mL	[23]
		HT29	IC50: 121.71 µg/mL	[23]