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The main amino acid residues from SARS-CoV-2 nsp14 ExoN that interact with (A) fisetin and (B) myricetin in the presence of one Mg(II) ion, and (C) fisetin and (D) myricetin in the presence of two Mg(II) ions. The interactive and catalytic amino acid residues are in beige and cyan, respectively; fisetin and myricetin are in gray and purple, respectively. Mg(II) ions are represented as green spheres. Hydrogen, oxygen, and nitrogen are shown in white, red, and dark blue, respectively.
