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. 2022 Jul 4;9(7):214. doi: 10.3390/jcdd9070214

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Loss of Hand1 and Hand2 in post-natal CCS results in intermediate phenotype. (A) PR intervals (in seconds) in Lead I ECG analysis from male Cntn2^Cre-EGFP/+; Hand1^fx/fxHand2^fx/fx (H1H2DKOs, open red symbols, n = 7) and Hand1^fx/xfHand2^fx/fx (H1H2control, open black symbols, n = 5) male mice at 5-week, 10-week, 15-week, 20-week, and 25-week time points. Identical symbols on the left of each line in graph represent the values of the same individual mouse across time points. Filled circles, medians; error bars, 25th and 75th percentiles. * p < 0.05, # p < 0.01 versus male H1H2control. (B) PR intervals (in seconds) in Lead I ECG analysis from female Cntn2^Cre-EGFP/+; Hand1^fx/fxHand2^fx/fx (H1H2DKOs, open red symbols, n = 7) and Hand1^fx/xfHand2^fx/fx (H1H2control, open black symbols, n = 4) female mice at 5-week, 10-week, 15-week, 20-week, and 25-week time points. Identical symbols on the left of each line in graph represent the values of the same individual mouse across time points. Filled circles, medians; error bars, 25th and 75th percentiles. # p < 0.01 versus female H1H2control.