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. 2022 Jul 7;11(14):2136. doi: 10.3390/cells11142136

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CeapinA7 and GSK621 inhibit GREM1-induced CRC cellline invasion and migration. (A) The GSEA was performed using an in-house RNA-seq dataset to identify gene sets in the KEGG collections that have positive correlations with GREM1 expression. The negative regulating PERK-mediated UPR (NES = 1.6542 NP = 0.0000) and ATF6-mediated UPR signaling pathway (NES = 1.3553, NP = 0.0000) with GREM1 overexpression in HCT116 cells. (B) HCT116 pLV-GREM1 and SW480 pLV-GREM1 cells were seeded into Matrigel-coated inserts with medium containing CeapinA7 (16 μM) or GSK621 (30 μM) and incubated for 36 h, followed by the invasion assay. (C,D) Wound healing test revealed that CeapinA7 and GSK621 inhibited cell migration.