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Amino acid sequences of the Cre-VP64 transactivator variants aligned to the sequence of the native P1 Cre recombinase. The NLS sequence is highlighted in bold. The VP64 transactivation domain with the S(GGGGS)3 linker is highlighted in blue. Amino acid substitutions in catalytically and synaptically deficient mutant variants are highlighted in red, and the corresponding amino acids in the native sequence are highlighted in green.
