Figure 11.

Colocalization of NLRP1 with ASC, phosphorylated tau (AT8), CD68, and HLA-DR in Alzheimer’s disease (A–C) and healthy control hippocampus (D). Open arrows in A show neurons in which NLRP1 inflammasome colocalizes with ASC protein. Full arrow in A shows presence of ASC proteins in a neuron in absence of NLRP1 inflammasome. Arrowheads in A show larger and brighter ASC signals that probably correspond to aggregates of self-oligomerized ASC protein, which are sometimes in the extracellular spaces of AD brains in association with NLRP1 (double arrowheads in A). AD brains generally show much higher expression of NLRP1 inflammasome (A,B) and HLA-DR-immunoreactive microglial cells (C) than healthy control brains (D). Scale bars = 10 μm.