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. 2022 Jul 15;14(7):1469. doi: 10.3390/pharmaceutics14071469

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Global phosphorylation-enriched proteins separated by treatment group and represented by scatterplots comparing fold enrichment score (FE) against −Log10 transformed p-values. Top ten cellular processes and pathways assessed by total fold enrichment score queried through the three GO databases; (a) BP, (b) CC, (c) MF, and (d) KEGG pathway databases demonstrate highly varied upstream protein PTM modifications unique to each treatment group with convergence of effect observed in proteins associated with maintenance of structural integrity of the cell. n = 4 per treatment group.

Global phosphorylation-enriched proteins separated by treatment group and represented by scatterplots comparing fold enrichment score (FE) against −Log10 transformed p-values. Top ten cellular processes and pathways assessed by total fold enrichment score queried through the three GO databases; (a) BP, (b) CC, (c) MF, and (d) KEGG pathway databases demonstrate highly varied upstream protein PTM modifications unique to each treatment group with convergence of effect observed in proteins associated with maintenance of structural integrity of the cell. n = 4 per treatment group.