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(a) The architectural domain of the IR (αβ) 2 homodimer. Black lines indicate the intersubunit disulfide bonds; (b) Inactive and active states of the IR; L1, L2, leucine-rich repeat domains 1, 2; CR, cysteine-rich domain; FnIII-1, 2, 3, fibronectin type-III domains 1, 2, 3; αCT, α C-terminal regions; TM, transmembrane; JM, juxtamembrane; KD, kinase domain; CT, C-terminal tail; ECD, ectodomain; TMD, transmembrane domain; TKD, tyrosine kinase domain.
