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. 2022 Jul 13;14(7):1460. doi: 10.3390/pharmaceutics14071460

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Tumor growth curves of (A) CT26 and (B) MC38 tumor-bearing mice after administration of the different therapeutic groups. Checkpoint inhibitors were given days 3, 6 and 9 after tumor implantation and ⁹⁰Y-GZP was given on day 12 (indicated by arrows). High dose of ⁹⁰Y-GZP (22.2 MBq) after ICI achieved complete tumor response in both tumor models. * Statistically significant compared to all other groups (p < 0.05).