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. 2022 Jul 15;14(14):3452. doi: 10.3390/cancers14143452

Figure 3.

Figure 3

Blocking EML4-ALK trimerization. The illustration on the left shows how oligomerization via the trimerization domain of EML4 (dotted areas, coloured light blue) and the phosphorylation (P) of the ALK tyrosine kinase domain leads to ALK activation and downstream signalling. On the right, a synthetic peptide (EML4cc) analogous to the trimerization domain coiled-coil sequence (red star) blocks EML4-ALK trimerization through competitive TD binding and is shown to prevent activation of EML4-ALK.