Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 15;14(14):3452. doi: 10.3390/cancers14143452

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Combination of microtubule poisons and ALK inhibitors in EML4-ALK-driven NSCLC. Microtubules are dynamic structures and the balance between their polymerization and depolymerization determines microtubule stability. The microtubule poisons, vincristine and paclitaxel, promote the depolymerization and polymerization of microtubules, respectively. EML4-ALK V3 strongly stabilizes microtubules, whereas EML4-ALK V1 has a weak destabilizing effect. In combination with ALK TKIs, microtubule poisons that act in the same direction of microtubule stability could lead to enhanced loss of cell viability in EML4-ALK V1 and V3 patient tumours.