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. 2022 Jun 29;14(7):1381. doi: 10.3390/pharmaceutics14071381

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Anti-EGFR/PD-L1 BsAbs exhibited potent antitumor activity in MDA-MB-231 tumor xenograft study. Five million MDA-MB-231 cells were injected in left flank of athymic nude mice. Treatment conditions: saline, ATE, Cetux and anti-EGFR/PD-L1 BsAbs were given intraperitoneally at 10 mg/kg body weight twice a week. (A) The images of the excised tumors at the end of the treatments. (B) Tumor volume was calculated after removing the tumors from mice at the end of treatment course on day 29; *, p < 0.05; **, p < 0.01. (C) Tumor growth curve over the course of treatment. (D) Mouse body weights in each treatment group were measured over the course of treatment.