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. 2022 Apr 6;57(3):594–614. doi: 10.1111/jre.12989

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© 2022 The Authors. Journal of Periodontal Research published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Identification and validation of the top five upregulated circRNAs expression. (A) Relative expression of five selected circRNAs on high‐throughput sequencing results. (B‐F) Relative expression of circRNAs in gingival tissues from patients with periodontitis (n = 30) and periodontal healthy donors (n = 26) by RT‐qPCR analysis, including circPTP4A2 (B), chr22:23101560‐23135351+ (C), circARHGEF28 (D), circBARD1 (E) and circRASA2 (F). Box and whiskers from Min to Max, showing all points. Significance was expressed as: *p < .05, **p < .01, ***p < .001 and ****p < .0001