FIGURE 4.

Correlation between relative expression levels of the top five upregulated circRNAs and probing depth. (A) Spearman's correlation analysis was used to assess correlations between circRNA relative expression and probing depth. p < .05 was considered statistically significant. (B) Participants were further divided based on their gender. Four subgroups included male healthy, female healthy, male periodontitis, and female periodontitis. Two‐way ANOVA was used to compare relative expression levels among gender subgroups. (C) Correlations between circRNA relative expression and probing depth were analyzed using Spearman's correlation analysis in male and female participants respectively. Significance was expressed as: *p < .05, **p < .01, ***p < .001, and ****p < .0001