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Nephron sites and target ion channels with approximate natriuresis/diuresis effect of the various diuretic classes. Cl, chloride; ENaC, epithelial sodium channel; GFR, glomerular filtration rate; K, potassium; IV, intravenous; Na, sodium; RAAS, renin–angiotensin–aldosterone system; SE, side effect; SGLT2, sodium–glucose cotransporter 2.
